The first step you should consider when you plan on playing any game of chance is defining your goals. For every purpose, there are several strategies. To win at ComeOn, it is necessary to follow the methods which suit your goals best. Also, note that these tips and tricks are meant for casual play - serious players should consider more efficient bets.
The first aspect of the game strategy concerns how much you are willing to spend per game/session and how many games/sessions you would like to play at once. It is called your bankroll management. For example, if you want to bet $2 per game or session, playing 1-2 games at once, you can't afford to wait for very long if you are losing several games in a row.
On the flip side, if you are paying $10 per game or session, with one match per day or less, it wouldn't be wise to check your results every 5 minutes (unless your pot is rising fast).
If you want to use a strategy that involves long shots, such as the Martingale system, it is wise to play with a small bankroll. Even if you lose several games in a row, you can keep playing and try your chances again and again until fortune favors you and gives back what was lost.